When to Use Silyl Ether?
Silyl Ethers Are Usually Used as Protecting Groups for Alcohols in Organic Synthesis. Since R1R2R3 Can Be Combinations of Differing Groups Which Can Be Varied...
Silyl ethers are usually used as protecting groups for alcohols in organic synthesis. Since R1R2R3 can be combinations of differing groups which can be varied in order to provide a number of silyl ethers, this group of chemical compounds provides a wide spectrum of selectivity for protecting group chemistry.
What is the purpose of silyl ether?
Silyl ether groups, typically used to protect alcohol functions in organic synthesis, offer good control over the rate and mechanism of their cleavage through judicious choice of silicon substituents.
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Which base is used for preparation of silyl ether?
The most common method for attaching this group reacts the alcohol with tert-butyldimethylsilyl chloride using imidazole65a or dimethylaminopyridine65b as the base. The analogous silyl triflate (t-BuMe2SiOSO2CF3) is also useful for generating this ether from alcohols, with an amine base.
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