When Tretinoin Stop Working?
If You're Using Topical Tretinoin to Reduce Fine Wrinkles, Discoloration, Age Spots, and/or Rough Feeling Skin, It Can Take 3–4 Months or up to Six Months...
If you're using topical tretinoin to reduce fine wrinkles, discoloration, age spots, and/or rough feeling skin, it can take 3–4 months or up to six months before you see results. If you stop using the medication or are inconsistent with your treatment, any improvements you see may disappear over time (NIH, 2019).
Does tretinoin work permanently?
Tretinoin works best when used within a skin care program that includes protecting the treated skin from the sun. However, it does not completely or permanently erase these skin problems or greatly improve more obvious changes in the skin, such as deep wrinkles caused by the sun or the natural aging process.
Can you build up a tolerance to tretinoin?
Over days and weeks of use, your skin will build a level of tolerance to tretinoin. But in the meantime, talk to your healthcare provider for help in adjusting the concentration of tretinoin you're using or applying it less often for a while.
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