Where Are G-Quadruplexes Located in the Human Transcriptome?
Certain G-Rich Dna Sequences Readily Form Four-Stranded Structures Called G-Quadruplexes. These Sequence Motifs Are Located in Telomeres as a Repeated Unit...
Certain G-rich DNA sequences readily form four-stranded structures called G-quadruplexes. These sequence motifs are located in telomeres as a repeated unit, and elsewhere in the genome, where their function is currently unknown.
Where are g-quadruplexes found?
Telomeres, rich in guanine and with a propensity to form g-quadruplexes, are located at the terminal ends of chromosomes and help maintain genome integrity by protecting these vulnerable terminal ends from instability. These telomeric regions are characterized by long regions of double-stranded CCCTAA:TTAGGG repeats.
What is AG quadruplex?
G-quadruplexes are noncanonical nucleic acid structures formed from stacked guanine tetrads. They are frequently used as building blocks and functional elements in fields such as synthetic biology and also thought to play widespread biological roles.
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