Where Are Pomc Neurons

POMC neuronal cells are mostly located in the hypothalamus and release bioactive molecules (melanocortins) as a result of the post-translational cleavage of POMC, which signals via specialized brain metabolic receptors (melanocortin receptor type 4 (MC4R)) to modulate food intake and systemic energy metabolism2.

Where are POMC neurons located?

In the CNS, cell bodies for POMC are mainly located in the arcuate nucleus of the hypothalamus and the nucleus tractus solitarius of the brainstem. Both of these areas have well defined functions relating to appetite and food intake.

What are Anorexigenic neurons?

Multiple “anorexigenic” neuronal populations within CNS receive the “inhibitory” GABAergic input from the NPY/AgRP neurons (Fig. 2). The ARH POMC neurons receive GABAergic input from the NPY/AgRP neurons, which form a local circuit of appetite regulation within the ARH (3).