Where Do Aldosterone Antagonists Work?

The aldosterone antagonists (spironolactone, eplerenone) act on the collecting duct of the nephron, competing with aldosterone for the mineralocorticoid receptor and preventing aldosterone-induced potassium excretion and sodium resorption [13].

How do aldosterone receptor antagonists work?

They work by inhibiting the effects of aldosterone, a mineralocorticoid hormone secreted by the adrenal gland. Aldosterone release causes retention of sodium and water, which causes increased blood volume, and a subsequent increase in blood pressure. Aldosterone receptor antagonists block the effects of aldosterone.

Where do aldosterone antagonists like spironolactone have their effects?

The aldosterone antagonist spironolactone blocks the effects of aldosterone on the renal distal convoluted tubule and collecting duct and thereby decreases sodium reabsorption and potassium excretion.