Where Does Oligomycin Bind?

Sarah Jenkins
Sarah Jenkins
• • 6 min read

Oligomycin Is a Group of Streptomyces Macrolides That Bind to the Oligomycin Sensitivity-Conferring Protein (Oscp Oscp Atp Synthase Delta Subunit Is a Subunit...

Where Does Oligomycin Bind?

Oligomycin is a group of Streptomyces macrolides that bind to the Oligomycin sensitivity-conferring protein (OSCP

OSCP
ATP synthase delta subunit is a subunit of bacterial and chloroplast F-ATPase/synthase. It is known as OSCP (oligomycin sensitivity conferral protein) in mitochondrial ATPase (note that in mitochondria there is a different delta subunit, ATP synthase delta/epsilon subunit).
› ATP_synthase_delta › OSCP_subunit
) at the F(o) subunits 6 and 9 which are found in the stalk of the F1F0-ATPase complex. This binding blocks proton conductance across the synthase complex and inhibits the synthesis of mitochondrial ATP.

How does oligomycin affect electron transport chain?

Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Oligomycins are macrolides created by Streptomyces that can be poisonous to other organisms.

Must Read

How does oligomycin inhibit electron transport chain?

Antimycin prevents the transfer of electrons through the cytochrome b-c complex. Oligomycin is an antibiotic that inhibits ATP synthase. It works by binding to the stalk of ATP synthase. This prevents proton re-entry into the inner mitochondrial matrix.

Sarah Jenkins

Sarah Jenkins

Senior Technology Editor & AI Specialist
Twitter Linkedin Github

Sarah Jenkins is a veteran tech journalist with over 12 years of experience covering artificial intelligence, mobile innovations, and digital ethics. Her insights have appeared in leading technology publications worldwide.