Where Does Pyrimidine Synthesis Occur?

Pyrimidine synthesis takes place in cytoplasm. Pyrimidine is synthesized as a free ring and then a ribose-5-phosphate is added to yield direct nucleotides, whereas, in purine synthesis, the ring is made by attaching atoms on ribose-5-phosphate.

Which step of pyrimidine biosynthesis occurs in mitochondria?

De novo biosynthesis of pyrimidine

This is the regulated step in the pyrimidine biosynthesis in bacteria. Ring formation and Dehydration. Dihydroorotate then enters the mitochondria where it is oxidized through removal of hydrogens. This is the only mitochondrial step in nucleotide rings biosynthesis.

Where does nucleotide synthesis occur in the cell?

De novo purine nucleotide synthesis occurs actively in the cytosol of the liver where all of the necessary enzymes are present as a macro-molecular aggregate.