Where Does Steroidogenesis Occur?

Of note, steroidogenesis is a multi-step process that occurs in two organelles, the endoplasmic reticulum (ER) and the mitochondrion.

Where in the cell does steroid biosynthesis occur?

Many of the enzymes for sterol and steroid synthesis are localized in the smooth-surfaced endoplasmic reticulum (2, 3). This organelle is particularly prominent in cells of the inner zones of the adrenal and fluctuates in amount and configuration in response to hormonal stimulation and sterol levels (4–7).

What is adrenal steroidogenesis?

Steroidogenesis in the adrenal cortex describes a series of consecutive enzymatic reactions converting a precursor hormone into intermediates on their way to active steroid hormones for 3 major steroid classes: mineralocorticoids (MCs), glucocorticoids (GCs), and precursors of active androgens (and ultimately, ...