Where Dopamine Receptors Located?

Dopamine receptors are expressed in the central nervous system, specifically in the hippocampal dentate gyrus and subventricular zone. Dopamine receptors are also expressed in the periphery, more prominently in kidney and vasculature, There are five types of dopamine receptors, which include D1, D2, D3, D4, and D5.

Where are most dopamine receptors located?

Dopamine receptors are most abundant in pituitary and brain, particularly in the basal forebrain, but they are also found in the retina and peripheral organs such as the kidney. Stimulation of dopamine receptors modulates natriuresis in the kidney and cell division and hormone synthesis and secretion in the pituitary.

Where are dopamine D2 receptors located?

D2 are highly expressed in the caudate, putamen (basal ganglia), nucleus accumbens, ventral tegmental area and the substantia nigra and in lower concentrations in the septal region, amygdala, hippocampus, thalamus, cerebellum and cerebral cortex.