Where Is Diazepam Metabolized?

Diazepam is metabolized in the liver. The common intermediate metabolite of diazepam and clorazepate, N-desmethyldiazepam (nordiazepam), is in turn biotransformed to the active compound, oxazepam.

Where is diazepam metabolised?

Diazepam is primarily metabolized via CYP2C19 and CYP3A4 to the major active metabolite (desmethyldiazepam), which is found in the plasma at concentrations equivalent to diazepam. Two minor active metabolites include temazepam and oxazaepam, which are usually not detectable.

Is diazepam bad for your kidneys?

For people with kidney disease: Diazepam is removed from your body by your kidneys. If you have kidney problems, more of the drug may stay in your body for longer, putting you at risk for side effects.