Where Is Hexokinase Found?

Glucokinase

(hexokinase D) is a monomeric cytoplasmic enzyme found in the liver and pancreas that serves to regulate glucose levels in these organs.

Where is hexokinase located in the cell?

It is the hexokinase found in muscle and heart. Hexokinase II is also located at the mitochondria outer membrane so it can have direct access to ATP. The relative specific activity of hexokinase II increases with pH at least in a pH range from 6.9 to 8.5.

Is hexokinase found in the cytosol?

Hexokinase I and II were found in the cytosol and bound to mitochondrial membranes; the percentage of membrane-bound enzyme activity increased with the grade of transformation from 32% of total activity in normal liver up to 69% in dedifferentiated tumor cells.