Where Is Oxaloacetate Found?

Once in the cytosol, malate is oxidized to oxaloacetate again using NAD+. Then oxaloacetate remains in the cytosol, where the rest of reactions will take place.

What is oxaloacetate made from?

Rather, oxaloacetate is formed by the carboxylation of pyruvate, in a reaction catalyzed by the biotin-dependent enzyme pyruvate carboxylase. ... If the energy charge is high, oxaloacetate is converted into glucose. If the energy charge is low, oxaloacetate replenishes the citric acid cycle.

Does glycolysis produce oxaloacetate?

Under anaerobic conditions, the reductive pathway of TCA cycle is activated, since succinate is the H-acceptor instead of oxygen, and pyruvate, originated from glycolysis, is converted to oxaloacetate, malate, fumarate, and then succinate (Fig. 9.1B).