Which Antidepressant Is the Best Tolerated?

Overall, citalopram appears to be the best-tolerated SSRI, followed by fluoxetine, sertraline, paroxetine, and fluvoxamine

. The latter 2 drugs are associated with the most side effects and the highest discontinuation rates because of side effects in clinical trials.

What is the most tolerated antidepressant?

Bupropion, citalopram, escitalopram, and sertraline were better tolerated than the other antidepressants. Escitalopram and sertraline were found to have the best combination of efficacy and acceptability. Efficacy results.

Which antidepressant has the least amount of side effects?

Selective serotonin reuptake inhibitors (SSRIs).

These medications generally cause fewer bothersome side effects and are less likely to cause problems at higher therapeutic doses than other types of antidepressants are.