Which Cells Make Pepsinogen?

Gastric chief cells secrete pepsin as an inactive zymogen called pepsinogen. Parietal cells

within the stomach lining secrete hydrochloric acid that lowers the pH of the stomach.

What is pepsinogen produced by?

Pepsinogens are synthesized and secreted primarily by the gastric chief cells of the human stomach before being converted into the proteolytic enzyme pepsin, which is crucial for digestive processes in the stomach.

What secretory cell types releases pepsinogen?

Chief cells release pepsinogen, which is activated to become pepsin by the acidic pH of the stomach and promotes protein breakdown. G cells release gastrin from the antrum of the stomach to encourage acid secretion by parietal cells.