Which Drugs Cause Hemorrhagic Cystitis?

Drug-induced hemorrhagic cystitis. The most common pharmacologic causes of hemorrhagic cystitis are the oxazaphosphorine-alkylating agents cyclophosphamide and ifosfamide. Unfortunately, the toxicity of these drugs is not insignificant, and many of the adverse effects are urologic.

What is drug-induced cystitis?

Most cases are diagnosed in women. The condition can be difficult to diagnose and treat. Drug-induced cystitis. Certain medications, particularly the chemotherapy drugs cyclophosphamide and ifosfamide, can cause inflammation of your bladder as the broken-down components of the drugs exit your body.

What causes hemorrhagic cystitis in cyclophosphamide?

Cyclophosphamide causes hemorrhagic cystitis by renal excretion of its hepatic metabolite, acrolein, which is urotoxic.