Which Is an Antiglobulin Test?

A laboratory test to identify antibodies that can bind to the surface of red blood cells or platelets and destroy them. This test is used to diagnose certain blood disorders in which patients make antibodies to their own red blood cells or platelets. It is also used to determine blood type.

What are the two tests that require the Antiglobulin test?

There are two types of Coombs tests. The direct test looks for antibodies that are stuck to red blood cells. The indirect test looks for antibodies floating in the liquid part of your blood, called serum.

What is a positive Antiglobulin test?

A positive DAT means that there are antibodies attached to the RBCs. In general, the stronger the DAT reaction (the more positive the test), the greater the amount of antibody bound to the RBCs, but this does not always equate to the severity of symptoms, especially if the RBCs have already been destroyed.