Which Is Better Zoloft or Paxil?

Is Paxil or Zoloft more effective? In a randomized, double-blind study comparing the two drugs for the treatment of panic disorder, Paxil and Zoloft were found to be equally effective; however, Zoloft was slightly better tolerated, and patients did better when discontinuing the drug.

What's the difference in Paxil and Zoloft?

Zoloft (sertraline) is good for treating depression and anxiety, but it can interact with many medicines. Improves mood and anxiety. Paxil (paroxetine) is effective for treating depression and anxiety, but causes more unwanted side-effects than other medicines that work like it.

Does Paxil have more side effects than Zoloft?

Paxil and Zoloft are both antidepressant drugs. The term “antidepressant” is a bit misleading because these medications aren't only used to treat depression. They're also used to treat anxiety disorders. In separate clinical trials, people who took Paxil reported more side effects than people who took Zoloft.