Which Mutation Is the Most Significant?

Deletion and insertion may cause what's called a FRAMESHIFT, meaning the reading frame changes. These are typically one of the most serious types of mutations.

What is the most significant type of mutation?

Types of Mutations

Germline mutations occur in gametes. These mutations are especially significant because they can be transmitted to offspring and every cell in the offspring will have the mutation. Somatic mutations occur in other cells of the body.

Which mutation is the most severe?

Deletion mutations, on the other hand, are opposite types of point mutations. They involve the removal of a base pair. Both of these mutations lead to the creation of the most dangerous type of point mutations of them all: the frameshift mutation.