Which Sedative Is Safe in Pregnancy

The antihistamines diphenhydramine and doxylamine are safe at recommended doses during pregnancy, even for extended periods. (These are the ingredients found in Benadryl, Diclegis, Sominex, and Unisom, for example.) Be aware that taking more than the recommended dose of any sleep medication can be harmful.

What sedatives are safe during pregnancy?

Benzodiazepines, including Ativan (lorazepam) and Klonopin (clonazepam) may also be useful. There is some controversy regarding the use of benzodiazepines during pregnancy.

Is diazepam safe in pregnancy?

The available literature suggests that it is safe to take diazepam during pregnancy but not during lactation because it can cause lethargy, sedation, and weight loss in infants. The use of chlordiazepoxide during pregnancy and lactation seems to be safe.