Who Can Get Hyperkeratosis?

Epidermolytic hyperkeratosis is usually inherited in an autosomal dominant pattern. This means that one copy of a mutated gene is able to cause the disorder and can be inherited from either parent. If one parent is affected, each child has a 50% chance of inheriting the disease.

What deficiency causes hyperkeratosis?

It can be caused by vitamin A deficiency or chronic exposure to arsenic. Hyperkeratosis can also be caused by B-Raf inhibitor drugs such as Vemurafenib and Dabrafenib.

How serious is hyperkeratosis?

Symptoms of Severe Hyperkeratosis

Symptoms include significant heavy callus on the bottom of the feet which can crack and cause considerable discomfort and will occasionally lead to infection. It can also affect the toenails causing thickening and crumbling and in some cases it can affect the hands.