Why Are Polycyclic Aromatic Hydrocarbons Carcinogenic?

Polycyclic aromatic hydrocarbons (PAHs) are a class of widespread environmental carcinogens. ... It has been established that PAHs, after metabolic activation in vivo, are capable of inducing mutations in oncogenes and, by inducing multiple mutations, may result in tumors.

How do polycyclic aromatic hydrocarbons cause cancer?

Repeated skin contact to the PAH naphthalene can result in redness and inflammation of the skin. Breathing or swallowing large amounts of naphthalene can cause the breakdown of red blood cells. Long-term exposure to low levels of some PAHs have caused cancer in laboratory animals.

Is polycyclic aromatic hydrocarbons cancer?

PAHs generally have a low degree of acute toxicity to humans. The most significant endpoint of PAH toxicity is cancer. Increased incidences of lung, skin, and bladder cancers are associated with occupational exposure to PAHs.