Why Deamidation Is Important?

In a protein or peptide, these reactions are important because they may alter its structure, stability or function and may lead to protein degradation.

What is the purpose of Deamidation?

Deamidation commonly affects asparagine (Asn or N) residues of proteins, but can also affect glutamine (Gln or Q) residues. 5 Deamidation in vivo is thought to play an important role in aging, acting as a molecular timer for certain biological processes.

Which amino acids can undergo Deamidation?

Three amino acids can be deaminated directly: glutamate (catalysed by glutamate dehydrogenase), glycine (catalysed by glycine oxidase) and serine (catalysed by serine dehydrogenase).