Why Do Antipyretics Work?

Antipyretics cause the hypothalamus to override a prostaglandin-induced increase in temperature. The body then works to lower the temperature, which results in a reduction in fever. Most antipyretic medications have other purposes.

How do antipyretics work in the body?

Antipyretics work by reducing prostaglandin synthesis. Synthesis of prostaglandin such as PGE 2 requires the enzyme cyclooxygenase. The substrate for cyclooxygenase is arachidonic acid. Antipyretic medications mostly are inhibitors of cyclooxygenase (COX) enzymes.

Why do we give antipyretics?

The principal benefit of the antipyretic drug is to make children more comfortable and to relieve the parents' anxiety. Febrile seizures are usually benign and does not cause brain damage. Its prevention is difficult and may not be achievable. Antipyretics can not prevent FS.

James H. Sterling

James H. Sterling

Environmental Science & Climate Journalist

James Sterling reports on renewable energy developments, climate policy, ecological conservation, and green tech innovations around the globe.