Why Do Fibrates Cause Gallstones?

Fibrates decrease the synthesis of bile acid by down-regulation of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase expression, therefore making it easier for cholesterol to precipitate and increasing the risk for gallstones.

Can fenofibrate cause gallstones?

This medicine may increase your risk of having gallstones. Check with your doctor right away if you have severe stomach pain, especially after eating, with nausea and vomiting.

What is the mechanism of action of fibrates?

Fibrates stimulate cellular fatty acid uptake, conversion to acyl-CoA derivatives, and catabolism by the beta-oxidation pathways, which, combined with a reduction in fatty acid and triglyceride synthesis, results in a decrease in VLDL production.