Why Do Steroids Cause Bowel Perforation?

Although the pathophysiological mechanism is not understood clearly, it is claimed that steroids probably by disturbing the intestinal mucosal barrier, facilitate the intestinal perforation. The long term treatment with corticosteroids increases the risk of colon perforation.

Can prednisolone cause diverticulitis?

The most serious cases of diverticulitis are usually seen in geriatric patients, particularly in those taking medications that increase the likelihood of infection (e.g., prednisone).

Can steroids cause diverticulitis?

Several drugs are associated with an increased risk of diverticulitis, including steroids, opioids and nonsteroidal anti-inflammatory drugs, such as ibuprofen (Advil, Motrin IB, others) and naproxen sodium (Aleve).