Why Does Brimonidine Cause Miosis?

Brimonidine binds to those receptors and, by doing so, inhibits further release of neurotransmitter into the synaptic cleft. Thus, when brimonidine is introduced to the eye, the dilator muscle will experience reduced activity, causing less pupil dilation and resulting in a more miotic pupil (Figure 2).

Does brimonidine cause miosis?

Conclusions: Brimonidine tartrate caused significant miosis, especially under scotopic conditions, most likely from its alpha-2 adrenergic effect. Under photopic luminance conditions, the miotic effect was pronounced.

Does brimonidine constrict pupils?

Brimonidine 0.1% induced a significant reduction in pupil size without a significant change in refraction or visual acuity under scotopic conditions. Therefore, it may be effective for the reduction of glare and halos after refractive surgery.