Why Does Cordycepin End Transcription?
Triphosphate Cordycepin Can Be Incorporated into Rna and Inhibits Transcription Elongation and Rna Synthesis Due to the Absence of Hydroxyl Moiety at the 3'...
Triphosphate Cordycepin can be incorporated into RNA and inhibits transcription elongation and RNA synthesis due to the absence of hydroxyl moiety at the 3' position. ... For example, it can be incorporated into an RNA molecule, thus causing the premature termination of its synthesis.
Does cordycepin inhibit RNA synthesis?
The effect of cordycepin (3'-deoxyadenosine) on newly synthesized globin mRNA in cultured mouse fetal liver erythroid cells is investigated. ... These data thus indicate that cordycepin inhibits newly synthesized mRNA as effectively as it inhibits ribosomal and transfer RNA synthesis.
How does heparin block transcription initiation?
Heparin inhibits transcription by binding to RNA polymerase. ... This mutant σ would competitively inhibit the binding of holoenzyme and prevent the specific initiation of RNA chains at promoter sites.
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