Why Does Glandular Fever Cause Splenomegaly?

Rash presenting with infectious mononucleosis. Splenomegaly in IM occurs as a result of lymphocytic infiltration enlarging the spleen beyond protection from the rib cage and creating an organ that is susceptible to rupture either spontaneously or traumatically.

Can glandular fever cause an enlarged spleen?

Glandular fever can cause your spleen to swell. For the first month, avoid heavy lifting and sports or activities that might increase your risk of falling, as this may damage your spleen.

Is splenomegaly common in mono?

Enlarged spleen

Mononucleosis may cause enlargement of the spleen. In extreme cases, your spleen may rupture, causing sharp, sudden pain in the left side of your upper abdomen. If such pain occurs, seek medical attention immediately — you may need surgery.