Why Does Hyperaldosteronism Cause Metabolic Alkalosis?

Hyperaldosteronism – Loss of hydrogen ions in the urine occurs when excess aldosterone (Conn's syndrome) increases the activity of a sodium-hydrogen exchange protein in the kidney. This increases the retention of sodium ions whilst pumping hydrogen ions into the renal tubule.

How does primary hyperaldosteronism cause metabolic alkalosis?

The associated metabolic alkalosis in primary aldosteronism is due to increased renal hydrogen ion loss mediated by hypokalemia and aldosterone.

Can hyperaldosteronism cause metabolic alkalosis?

Hypersecretion of aldosterone is generally considered to be the proximate cause of metabolic alkalosis in primary aldosteronism and has also been invoked as an important factor in the genesis and maintenance of alkalosis in the postoperative patient.