Why Does Senescence Occur?
In Adult Tissues, Senescence Is Triggered Primarily as a Response to Damage, Allowing for Suppression of Potentially Dysfunctional, Transformed, or Aged Cells...
In adult tissues, senescence is triggered primarily as a response to damage, allowing for suppression of potentially dysfunctional, transformed, or aged cells. The aberrant accumulation of senescent cells with age results in potential detrimental effects.
What is the purpose of senescence?
Senescence is an irreversible form of long-term cell-cycle arrest, caused by excessive intracellular or extracellular stress or damage. The purpose of this cell-cycles arrest is to limit the proliferation of damaged cells, to eliminate accumulated harmful factors and to disable potential malignant cell transformation.
What causes cell senescence?
Abstract. Cellular senescence is a tumor suppressor response that acts as a barrier to cancer development and progression. In normal cells, diverse stimuli, including excessive mitogenic signaling, DNA damage or telomere shortening, trigger a senescence response characterized by stable growth arrest.
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