Why Granulocytes Have Lobed Nuclei?

Functional significance of a lobed nucleus. It is thought that the lobular arrangement makes the nucleus easier to deform and, hence, help the neutrophils pass through small gaps in the endothelium and extracellular matrix more easily (Hoffmann et al.

What is the function of lobed nucleus?

A unique feature of immune cells that have multiple lobes in their nuclei is that these cells can eject their DNA as traps. Neutrophils, eosinophils, and mast cells can expel their chromatin into the environment, killing themselves in the act but also forming nets that trap and kill foreign invaders.

What are lobes in granulocytes?

Lobation is a characteristic of the cell nucleus of certain granulocytes, which are types of white blood cells, where the nucleus is segmented into two or more connected lobes. Of the four types of granulocyte only the mast cell is not lobated. Lobation is also a characteristic of megakaryocytes in the bone marrow.