Why Is Adenocarcinoma Increasing?

Environmental factors such as smoking, drinking, and obesity have long been known to be associated with an increased incidence of gastric and esophageal cancers. It is also well recognized that gastroesophageal reflux plays a role in causing esophageal cancer.

Why is incidence of oesophageal adenocarcinoma increasing?

In the West, the incidence of esophageal adenocarcinoma, which is a long-term complication of damage by gastroesophageal reflux, has been rising over recent decades. Two main factors are likely to account for this increase. The first is the rising incidence of central obesity which promotes gastroesophageal reflux.

Why is lung adenocarcinoma increasing?

In females and non-smoker males, the increase could be partly due to a detection bias in former studies. Nevertheless, successive cohorts over time seem more likely to develop adenocarcinoma and less likely to develop squamous cell carcinoma.