Why Is Androgen Insensitivity Syndrome?

AIS is caused by a genetic alteration that is passed along the female line to the child. Although people with AIS have XY (usual male pattern) chromosomes, the body does not respond to testosterone (the sex hormone) fully or at all. This prevents the sex development of a typical male.

How do you explain androgen insensitivity syndrome?

Androgen insensitivity syndrome (AIS) is when a person who is genetically male (who has one X and one Y chromosome) is resistant to male hormones (called androgens). As a result, the person has some of the physical traits of a woman, but the genetic makeup of a man.

Why does the breast develop in androgen insensitivity syndrome?

Robust breast development occurs at puberty that is due to peripheral aromatization of testosterone to estrogen. There is usually scant or absent pubic and axillary hair with some vulvar hair. The vagina is short and blind-ending, and müllerian structures (cervix, uterus, fallopian tubes) are absent.

Alexander Ross

Alexander Ross

Gaming, Esports & Interactive Media Writer

Alexander Ross has covered the video game industry for a decade, writing deep dives on game design, esports tournaments, VR developments, and gaming culture.