In Light of Previous Laboratory Studies of the Antihistamine Compound at Ucsf, the Researchers Said, the Drug Most Likely Exerted Its Effect by Repairing...
In light of previous laboratory studies of the antihistamine compound at UCSF, the researchers said, the drug most likely exerted its effect by repairing damage MS had inflicted on myelin, an insulating membrane that speeds transmission of electrical signals in the nervous system.
Do Antihistamines help multiple sclerosis?
Clemastine enters the brain and causes drowsiness, so it is known as a sedating antihistamine. The treatment has been shown to suppress the immune system both in mice and healthy volunteers, which could be useful in MS. It's also been shown to promote myelin repair in mice with a condition similar to MS.
Clemastine fumarate was first approved by the Food and Drug Administration (FDA) in 1977. It is an antihistamine medication for allergies and has been available over the counter since 1993. Its potential to treat MS is therefore as surprising as it is welcome.
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