Why Is Intercalated Cells Important?

Intercalated cells are kidney tubule epithelial cells with important roles in the regulation of acid-base homeostasis. ... These cells appear in the late distal convoluted tubule

What is the purpose of intercalated cells?

Intercalated cells are epithelial cells traditionally associated with the regulation of acid-base homeostasis in distal segments of the kidney tubule (Figure 1) (1). These cells also participate in potassium and ammonia transport and have a role in the innate immune system.

What is the difference between principal cells and intercalated cells?

Principal cells are the main Na+ reabsorbing cells and the site of action of aldosterone, K+-sparing diuretics, and spironolactone. ... Type A intercalated cells mediate acid secretion and bicarbonate reabsorption. Type B intercalated cells mediate bicarbonate secretion and acid reabsorption.