Why Is There Antihistamine in Midol?

Why does Midol® Complete have an antihistamine as an active ingredient? Pyrilamine Maleate is an antihistamine active ingredient, and its purpose is to temporarily relieve bloating due to water retention during the menstrual period.

Why does menstrual relief have antihistamine?

Pyrilamine is an antihistamine often included in menstrual products. It is alleged to provide relief of emotional or mood changes (e.g., anxiety, nervous tension, irritability), reduce water-retention symptoms, and reduce severity of cramps and backache.

How does antihistamine help period cramps?

"And the antihistamines might somehow be acting on the calcium channels in the uterine muscles, which would prevent the cramps." So, the cocktail of substances might be more effective at treating some people's menstrual cramps than just a plain NSAID would.