Why Nifedipine Causes Gingival Hyperplasia?
[2] Various Factors Were Attributed for the Overgrowth of Gingiva in Nifedipine-Induced Hyperplasia, Which Include High Plaque Index (Poor Oral Hygiene), High...
[2] Various factors were attributed for the overgrowth of gingiva in nifedipine-induced hyperplasia, which include high plaque index (poor oral hygiene), high dose of the drug, genetic factors, individual susceptibility, and interaction between drugs and metabolites with the fibroblasts of gingiva.
Can nifedipine cause gingival hyperplasia?
The principal action of nifedipine is to inhibit the influx of extracellular calcium ions across the membranes of cardiac and vascular smooth muscle cells, without changing serum calcium concentration (1). One of the side effects of this drug is gingival hyperplasia which was first described in 1984 by Lederman (2).
Why do calcium channel blockers cause gingival hyperplasia?
The present study proposes a mechanism by which calcium channel antagonists may induce gingival hyperplasia. The calcium antagonist induces blockage of the aldosterone synthesis in zona glomerulosa of the adrenal cortex since this pathway is calcium-dependent, cyclic nucleotide-independent.
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