Why Sulfonamides Are Not Effective in Pus?
Because the Activity Is by Competitive Substitution, the Sulfonamide Tissue Concentration Must Be Kept High Enough to Prevent Bacterial Access to Paba...
Because the activity is by competitive substitution, the sulfonamide tissue concentration must be kept high enough to prevent bacterial access to PABA. Therefore the sulfonamides are ineffective in pus and necrotic tissue, which provide additional sources of PABA to the bacteria.
Why are sulfonamides not used?
Today, sulfonamides are seldom used as monotherapy because their spectrum is limited and resistance develops rapidly. Combined with a folate antagonist such as trimethoprim or pyrimethamine (Section 2.6. 16), sulfonamides are indicated among others in the treatment of toxoplasmosis and malaria.
What is sulfonamides effective against?
Sulfonamides are effective against Gram-positive and Gram-negative bacteria. Some protozoa, such as coccidians, Toxoplasma species and plasmodia, are generally sensitive. Chlamydia, Nocardia and Actinomyces species are also sensitive.
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