Why Use Alkylating Agent?
Alkylating Agents Keep the Cell from Reproducing (Making Copies of Itself) by Damaging Its Dna. These Drugs Work in All Phases of the Cell Cycle and Are Used...
Alkylating agents keep the cell from reproducing (making copies of itself) by damaging its DNA. These drugs work in all phases of the cell cycle and are used to treat many different cancers, including cancers of the lung, breast, and ovary as well as leukemia, lymphoma, Hodgkin disease, multiple myeloma, and sarcoma.
What is the purpose of alkylating agent?
Alkylating agents prevent cell division primarily by cross-linking strands of DNA. Because of continued synthesis of other cell constituents, such as RNA and protein, growth is unbalanced, and the cell dies. Activity of alkylating agents does not depend on DNA synthesis in the target cells.
Which are alkylating agents?
Cyclophosphamide — the most widely used alkylating agent of modern times. Chlormethine also known as mechlorethamine or mustine (HN2) — the first alkylating agent to receive regulatory approval.
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