Will Screen Protector Affect Apple Pencil?

The Apple Pencil is designed to make sure it does not cause any damage to the screen unless there is debris or a foreign object on it that is causing the damage. However, you can definitely still use it with a screen protector.

Does tempered glass wear out Apple Pencil?

From my research I found that while the Pencil will still work with a tempered glass protector, there is some line wobble, more noticeable when going slow and using pens/fine brushes. If you're just taking notes it might not be an issue, but if you're an illustrator you might want to go with the film style protectors.

Do matte screen protectors damage Apple Pencil tip?

Do you bear down on the Pencil to get it to write on the iPad screen? Also, because matte screen protectors have a “tooth” or texture to them, the friction of the screen protector's textured surface and the Pencil's plastic tip can wear down tip more than normal.