Will Ursodiol Make You Gain Weight?

Background: Ursodeoxycholic acid (UDCA) is the established treatment of primary biliary cirrhosis (PBC) and is a safe and well-tolerated medication. Nevertheless, patients often anecdotally complain of weight gain while on this drug.

What are the side effects of taking ursodiol?

Side Effects
  • Bladder pain.
  • bloody or cloudy urine.
  • difficult, burning, or painful urination.
  • fast heartbeat.
  • frequent urge to urinate.
  • severe nausea.
  • skin rash or itching over the entire body.
  • stomach pain.

Can you lose weight on ursodiol?

Results: Body mass index decreases significantly from 34.2 +/- 4.2 kg/m2 and 33.3 +/- 1.6 kg/m2 to 31.8 +/- 4.5 kg/m2 and 30.6 +/- 2.6 kg/m2 in the ursodeoxycholic acid and placebo groups, p < 0.001.

James H. Sterling

James H. Sterling

Environmental Science & Climate Journalist

James Sterling reports on renewable energy developments, climate policy, ecological conservation, and green tech innovations around the globe.