During an Ige-Mediated Hypersensitivity Reaction What Causes Bronchospasm?

In allergic bronchospasm inhaled allergen interacts with specific IgE antibody on the surface of mast cells, inducing the release of mediators, particularly histamine and leukotrienes, which induce bronchoconstriction

bronchoconstriction
Bronchoconstriction is a tightening of smooth muscle surrounding the bronchi and bronchioles with consequent wheezing and shortness of breath.
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What is IgE mediated hypersensitivity?

Type I hypersensitivity reactions involve the activation of tissue mast cells and blood basophils when IgE molecules bound to their surface become linked together by an allergen. Substantial numbers of individuals develop allergies due to type I (IgE-mediated) hypersensitivity, also referred to as atopic allergy.

Which of the following is an immunoglobulin E IgE )- mediated hypersensitivity reaction?

Type I hypersensitivity is also known as an immediate reaction and involves immunoglobulin E (IgE) mediated release of antibodies against the soluble antigen. This results in mast cell degranulation and release of histamine and other inflammatory mediators.

James H. Sterling

James H. Sterling

Environmental Science & Climate Journalist

James Sterling reports on renewable energy developments, climate policy, ecological conservation, and green tech innovations around the globe.