What is the best time to take hydrochlorothiazide?

If you are to take a single dose a day, take it in the morning after breakfast. If you are to take more than one dose a day, take the last dose no later than 6 p.m., unless otherwise directed by your doctor.

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When is the best time to take a water pill?

If you only need one dose a day, you might want to take your diuretic in the morning so you can sleep through the night instead of getting up to go to the bathroom. Avoid alcohol and medicines to help you sleep.